Package: MRAPSS
Title: The MRAPSS package implement the MR-APPSS approach to test for
        the causal effect of an exposure on a outcome disease.
Version: 0.0.0.9000
Authors@R: 
    person(given = "Xianghong",
           family = "HU",
           role = c("aut", "cre"),
           email = "maxhu@ust.hk",
           comment = c(ORCID = "0000-0001-5260-3936"))
Description: The MRAPSS package implement the MR-APPSS approach to test
        for the causal effects between an exposure and a outcome
        disease. The MR-APPSS is a unified approach to Mendelian
        Randomization accounting for polygenicity, pleiotropy and
        sample structure using genome-wide summary statistics.
        Specifically, MR-APPSS uses a background-foreground model to
        characterize both SNP-exposure effects and SNP-outcome effects
        estimates, where the background model accounts for confounding
        from genetic correlation and sample structure and the
        foreground model captures the valid signal for causal
        inference.
License: What license it uses
Encoding: UTF-8
LazyData: true
Imports: ggplot2, ggnewscale, dplyr, magrittr, ieugwasr (>= 0.1.4),
        readr, expm
Remotes: mrcieu/ieugwasr
RoxygenNote: 7.0.2
Depends: R (>= 3.5.0)
Suggests: knitr, rmarkdown
VignetteBuilder: knitr
Config/pak/sysreqs: libssl-dev libx11-dev
Repository: https://mrcieu.r-universe.dev
Date/Publication: 2026-04-30 10:09:51 UTC
RemoteUrl: https://github.com/YangLabHKUST/MR-APSS
RemoteRef: HEAD
RemoteSha: 7f390066eab78caaa1cce7e9f8329dda14a275c5
NeedsCompilation: no
Packaged: 2026-05-30 08:55:51 UTC; root
Author: Xianghong HU [aut, cre] (ORCID:
    <https://orcid.org/0000-0001-5260-3936>)
Maintainer: Xianghong HU <maxhu@ust.hk>