Package: MRAPSS
Title: Mendelian Randomization Accounting for Pleiotropy and Sample
        Structure
Version: 0.0.0.9000
Authors@R: 
    person(given = "Xianghong",
           family = "HU",
           role = c("aut", "cre"),
           email = "maxhu@ust.hk",
           comment = c(ORCID = "0000-0001-5260-3936"))
Description: Implements the MR-APSS approach to test for the causal
        effects between an exposure and an outcome disease. MR-APSS is
        a unified approach to Mendelian Randomization accounting for
        polygenicity, pleiotropy and sample structure using genome-wide
        summary statistics. Specifically, MR-APSS uses a
        background-foreground model to characterize both SNP-exposure
        effects and SNP-outcome effects estimates, where the background
        model accounts for confounding from genetic correlation and
        sample structure and the foreground model captures the valid
        signal for causal inference.
License: MIT + file LICENSE
Encoding: UTF-8
LazyData: true
LazyDataCompression: xz
Imports: ggplot2, dplyr, magrittr, ieugwasr (>= 0.1.4), readr, expm,
        data.table, mvtnorm, stats, utils
Remotes: mrcieu/ieugwasr
Depends: R (>= 2.10)
Suggests: knitr, rmarkdown
Config/roxygen2/version: 8.1.0
Config/pak/sysreqs: libssl-dev libx11-dev
Repository: https://mrcieu.r-universe.dev
Date/Publication: 2026-08-11 13:12:52 UTC
RemoteUrl: https://github.com/remlapmot/MR-APSS
RemoteRef: suggestions
RemoteSha: ac1e457511b91c8a0b555a048dfd963633ac89a9
NeedsCompilation: no
Packaged: 2026-10-08 15:38:14 UTC; root
Author: Xianghong HU [aut, cre] (ORCID:
    <https://orcid.org/0000-0001-5260-3936>)
Maintainer: Xianghong HU <maxhu@ust.hk>