Package: SlopeHunter
Type: Package
Title: Slope-Hunter: A ROBUST METHOD FOR COLLIDER BIAS CORRECTION IN
        CONDITIONAL GENOME-WIDE ASSOCIATION STUDIES
Version: 1.1.0
Date: 2022-09-27
Author@R: person("Osama", "Mahmoud", email = "o.mahmoud@essex.ac.uk",
        role = c("aut", "cre", "cph"), comment = c(ORCID =
        "0000-0003-0342-6704"))
Description: Studying genetic associations with prognosis (e.g.
        survival, disability, subsequent disease events) is problematic
        due to selection bias - also termed index event bias or
        collider bias - whereby selection on disease status can induce
        associations between causes of incidence with prognosis. The
        Slope-Hunter approach adjusts genetic associations for this
        bias assuming that the contribution of the set of genetic
        variants affecting incidence only to the heritability of
        incidence is at least as large as the contribution of those
        affecting both incidence and prognosis.
License: GPL-2 | GPL-3
URL: http://osmahmoud.com/SlopeHunter/
Encoding: UTF-8
LazyData: true
Depends: R (>= 3.5.0)
Imports: ggplot2 (>= 2.1.0), mclust, plotly, stats, ieugwasr,
        data.table (>= 1.14.2), dplyr, tools
Suggests: knitr (>= 1.12), rmarkdown (>= 0.9)
VignetteBuilder: knitr
RoxygenNote: 7.1.2
Author: Osama Mahmoud [aut, cre,
        cph](<https://orcid.org/0000-0003-0342-6704>)
Maintainer: Osama Mahmoud <o.mahmoud@essex.ac.uk>
Remotes: mrcieu/ieugwasr
Roxygen: list(markdown = TRUE)
Config/pak/sysreqs: cmake make libicu-dev libuv1-dev libssl-dev
Repository: https://mrcieu.r-universe.dev
Date/Publication: 2022-10-07 10:01:38 UTC
RemoteUrl: https://github.com/Osmahmoud/SlopeHunter
RemoteRef: HEAD
RemoteSha: b0686fe0c7a4e6d056d902765ba9cd0a0b35ad5c
NeedsCompilation: no
Packaged: 2026-06-18 09:11:43 UTC; root