{ "_id": "6a547d2cff0138dec5d64197", "Package": "GRAPPLE", "Title": "R Package for MR Framework GRAPPLE", "Version": "0.2.2", "Authors@R": "c(person(\"Jingshu\", \"Wang\", email = \"jingshuw@uchicago.edu\", role = c(\"aut\", \"cre\")), person(\"Qingyuan\", \"Zhao\", email = \"qyzhao@statslab.cam.ac.uk\", role = c(\"aut\")))", "Description": "Fitting and diagnosing two-sample summary data Mendelian\nrandomization with heterogeneous instruments.", "License": "GPL (>=2)", "Encoding": "UTF-8", "RoxygenNote": "7.3.3", "Repository": "https://mrcieu.r-universe.dev", "Date/Publication": "2026-03-15 11:24:26 UTC", "RemoteUrl": "https://github.com/remlapmot/GRAPPLE", "RemoteRef": "suggestions", "RemoteSha": "e11d53e9fa8bb909a5d50fe71998181e99b5f87a", "NeedsCompilation": "no", "Packaged": { "Date": "2026-07-13 05:49:57 UTC", "User": "root" }, "Author": "Jingshu Wang [aut, cre],\nQingyuan Zhao [aut]", "Maintainer": "Jingshu Wang ", "_user": "mrcieu", "_type": "src", "_file": "GRAPPLE_0.2.2.tar.gz", "_fileid": "https://r2.ropensci.org/acb28658651f4ee97b0ae44e4fdb461796fc6c10de831cf9d2ff80d19b7c02bb", "_filesize": 133529, "_sha256": "acb28658651f4ee97b0ae44e4fdb461796fc6c10de831cf9d2ff80d19b7c02bb", "_expires": "2026-10-21T05:52:43.000Z", "_created": "2026-07-13T05:49:57.000Z", "_published": "2026-07-13T05:52:44.783Z", "_jobs": [ { "job": 86744012006, "time": 131, "config": "linux-devel-x86_64", "r": "4.7.0", "check": "WARNING", "artifact": "8270242692" }, { "job": 86744012018, "time": 117, "config": "linux-release-x86_64", "r": "4.6.1", "check": "WARNING", "artifact": "8270238835" }, { "job": 86744012021, "time": 89, "config": "macos-oldrel-arm64", "r": "4.5.3", "check": "WARNING", "artifact": "8270237919" }, { "job": 86744012000, "time": 99, "config": "macos-release-arm64", "r": "4.6.1", "check": "WARNING", "artifact": "8270238001" }, { "job": 86743627133, "time": 169, "config": "source", "r": "4.6.1", "check": "OK", "artifact": "8270209155" }, { "job": 86744012008, "time": 96, "config": "wasm-release", "r": "4.6.0", "check": "OK", "artifact": "8270233594" }, { "job": 86744012014, "time": 110, "config": "windows-devel", "r": "4.7.0", "check": "WARNING", "artifact": "8270237932" }, { "job": 86744012029, "time": 95, "config": "windows-oldrel", "r": "4.5.3", "check": "WARNING", "artifact": "8270234081" }, { "job": 86744012019, "time": 84, "config": "windows-release", "r": "4.6.1", "check": "WARNING", "artifact": "8270230396" } ], "_host": "GitHub-Actions", "_buildurl": "https://github.com/r-universe/mrcieu/actions/runs/29227171054", "_status": "success", "_upstream": "https://github.com/remlapmot/GRAPPLE", "_commit": { "id": "e11d53e9fa8bb909a5d50fe71998181e99b5f87a", "author": "Tom Palmer ", "committer": "Tom Palmer ", "message": "Use data.table:: prefix\n", "time": 1773573866 }, "_maintainer": { "name": "Jingshu Wang", "email": "jingshuw@uchicago.edu" }, "_distro": "resolute", "_registered": true, "_dependencies": [ { "package": "R", "version": ">= 3.4.0", "role": "Depends" }, { "package": "stats", "role": "Imports" }, { "package": "ggplot2", "role": "Imports" }, { "package": "nortest", "role": "Imports" }, { "package": "data.table", "role": "Imports" }, { "package": "ggrepel", "role": "Imports" }, { "package": "dplyr", "role": "Imports" }, { "package": "plyr", "role": "Imports" }, { "package": "tools", "role": "Imports" }, { "package": "haploR", "role": "Suggests" } ], "_owner": "remlapmot", "_selfowned": false, "_usedby": 0, "_updates": [ { "week": "2026-11", "n": 8 } ], "_tags": [], "_stars": 0, "_contributors": [ { "user": "jingshuw", "count": 90, "uuid": 12014815 }, { "user": "qingyuanzhao", "count": 2, "uuid": 3944837 } ], "_userbio": { "uuid": 15654827, "type": "organization", "name": "MRC Integrative Epidemiology Unit", "followers": 251 }, "_downloads": { "count": 0, "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/GRAPPLE" }, "_devurl": "https://github.com/remlapmot/grapple", "_searchresults": 25, "_rbuild": "4.6.1", "_assets": [ "extra/citation.cff", "extra/citation.html", "extra/citation.json", "extra/citation.txt", "extra/contents.json", "extra/GRAPPLE.html", "extra/readme.html", "extra/readme.md", "manual.pdf" ], "_cranurl": false, "_exports": [ "findModes", "getInput", "grappleRobustEst", "qqDiagnosis", "rho.tukey", "robustLossFixtau" ], "_help": [ { "page": "computeQ", "title": "Compute the conditional Q-statistic for assessing instrument strength", "topics": [ "computeQ" ] }, { "page": "findModes", "title": "Use the multiple modes of the robust profile likelihood function to find out multiple pathways in MR and their marker SNPs.", "topics": [ "findModes" ] }, { "page": "getInput", "title": "Preprocess GWAS summary statistics datasets", "topics": [ "getInput" ] }, { "page": "grappleRobustEst", "title": "Robust multivariate MR estimation", "topics": [ "grappleRobustEst" ] }, { "page": "qqDiagnosis", "title": "QQ-plot diagnosis and outlier detection from standardized residuals", "topics": [ "qqDiagnosis" ] }, { "page": "rho.tukey", "title": "Tukey's beweight loss function and its derivatives", "topics": [ "rho.tukey" ] }, { "page": "robustLossFixtau", "title": "Calculate the robustified profile likelihood function", "topics": [ "robustLossFixtau" ] } ], "_readme": "https://github.com/remlapmot/GRAPPLE/raw/suggestions/README.md", "_rundeps": [ "cli", "cpp11", "data.table", "dplyr", "farver", "generics", "ggplot2", "ggrepel", "glue", "gtable", "isoband", "labeling", "lifecycle", "magrittr", "nortest", "pillar", "pkgconfig", "plyr", "R6", "RColorBrewer", "Rcpp", "rlang", "S7", "scales", "tibble", "tidyselect", "utf8", "vctrs", "viridisLite", "withr" ], "_score": 2.0969100130080562, "_indexed": false, "_nocasepkg": "grapple", "_universes": [ "mrcieu" ], "_binaries": [ { "r": "4.7.0", "os": "linux", "version": "0.2.2", "date": "2026-07-13T05:52:04.000Z", "distro": "resolute", "commit": "e11d53e9fa8bb909a5d50fe71998181e99b5f87a", "fileid": "https://r2.ropensci.org/ee127b28c550a150570557c5af15297f88a0e7d643f7f257b1e4fa5e6f974ad8", "status": "success", "check": "WARNING", "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/29227171054" }, { "r": "4.6.1", "os": "linux", "version": "0.2.2", "date": "2026-07-13T05:51:50.000Z", "distro": "resolute", "commit": "e11d53e9fa8bb909a5d50fe71998181e99b5f87a", "fileid": "https://r2.ropensci.org/d893233082893072bdcb071af4956b345572b8d0b0d271a7d9de1f4146c213c4", "status": "success", "check": "WARNING", "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/29227171054" }, { "r": "4.5.3", "os": "mac", "version": "0.2.2", "date": "2026-07-13T05:51:55.000Z", "commit": "e11d53e9fa8bb909a5d50fe71998181e99b5f87a", "fileid": "https://r2.ropensci.org/06aad22cee2e5653e7b7d4466e1884b4ca78d4c61126b0f3c0520a3aaeed853f", "status": "success", "check": "WARNING", "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/29227171054" }, { "r": "4.6.1", "os": "mac", "version": "0.2.2", "date": "2026-07-13T05:51:47.000Z", "commit": "e11d53e9fa8bb909a5d50fe71998181e99b5f87a", "fileid": "https://r2.ropensci.org/14ef09b5d64f1dcbbda3dc14716aeb56971ee1d31979e4266dc3eaf183c63de9", "status": "success", "check": "WARNING", "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/29227171054" }, { "r": "4.6.0", "os": "wasm", "version": "0.2.2", "date": "2026-07-13T05:51:53.000Z", "commit": "e11d53e9fa8bb909a5d50fe71998181e99b5f87a", "fileid": "https://r2.ropensci.org/2452483916020ad0fd2893f3c530a86ed7783186a04179f52a90f008b0e3fdf3", "status": "success", "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/29227171054" }, { "r": "4.7.0", "os": "win", "version": "0.2.2", "date": "2026-07-13T05:51:42.000Z", "commit": "e11d53e9fa8bb909a5d50fe71998181e99b5f87a", "fileid": "https://r2.ropensci.org/57fe773f9772937525d43cbe80c510e5cd078b6838846a9de35354d38c8ff0df", "status": "success", "check": "WARNING", "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/29227171054" }, { "r": "4.5.3", "os": "win", "version": "0.2.2", "date": "2026-07-13T05:51:25.000Z", "commit": "e11d53e9fa8bb909a5d50fe71998181e99b5f87a", "fileid": "https://r2.ropensci.org/e6c4bd0027030c90f35e8d12512172075d0ba0cb94a9c301aa40d3c55bb3d711", "status": "success", "check": "WARNING", "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/29227171054" }, { "r": "4.6.1", "os": "win", "version": "0.2.2", "date": "2026-07-13T05:51:09.000Z", "commit": "e11d53e9fa8bb909a5d50fe71998181e99b5f87a", "fileid": "https://r2.ropensci.org/3920696326cc46525e6acdadc95041d94c175027ad78ed1610eb556e4a4fcf82", "status": "success", "check": "WARNING", "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/29227171054" } ] }