{ "_id": "6a5340b29b92047c28d57210", "Package": "MR2", "Title": "Bayesian multi-response Mendelian randomisation", "Version": "0.1.1", "Date": "2025-03-01", "Authors@R": "as.person(c(\n\"Leonardo Bottolo [aut, cre]\",\n\"Verena Zuber [aut, ctb]\"))", "Maintainer": "Leonardo Bottolo ", "Description": "This package performs two-sample summary-level data\nBayesian multi-response Mendelian randomisation with the\nselection of important exposures shared or distinct across\nresponses. Post-processing and selection of exposures based on\nan in-house FDR implementation are also provided.", "BugReports": "https://github.com/lb664/MR2/issues", "License": "GPL-2 | file LICENSE", "Encoding": "UTF-8", "Roxygen": "list(markdown = TRUE)", "RoxygenNote": "7.3.2", "RdMacros": "Rdpack", "Config/pak/sysreqs": "libglpk-dev libxml2-dev", "Repository": "https://mrcieu.r-universe.dev", "Date/Publication": "2025-04-07 10:35:27 UTC", "RemoteUrl": "https://github.com/lb664/MR2", "RemoteRef": "HEAD", "RemoteSha": "ff1774747c312a1d53b747fbf7c161d6155b209e", "NeedsCompilation": "no", "Packaged": { "Date": "2026-07-12 06:57:45 UTC", "User": "root" }, "Author": "Leonardo Bottolo [aut, cre],\nVerena Zuber [aut, ctb]", "_user": "mrcieu", "_type": "src", "_file": "MR2_0.1.1.tar.gz", "_fileid": "https://r2.ropensci.org/6f20655246c651a23caa0eb057603983611748f1cf04db4db6ed0888eb299664", "_filesize": 451399, "_sha256": "6f20655246c651a23caa0eb057603983611748f1cf04db4db6ed0888eb299664", "_expires": "2026-10-20T07:22:24.000Z", "_created": "2026-07-12T06:57:45.000Z", "_published": "2026-07-12T07:22:26.016Z", "_jobs": [ { "job": 86625251926, "time": 1410, "config": "linux-devel-x86_64", "r": "4.7.0", "check": "WARNING", "artifact": "8257408627" }, { "job": 86625251928, "time": 1325, "config": "linux-release-x86_64", "r": "4.6.1", "check": "WARNING", "artifact": "8257396812" }, { "job": 86625251930, "time": 1086, "config": "macos-oldrel-arm64", "r": "4.5.3", "check": "WARNING", "artifact": "8257365041" }, { "job": 86625251921, "time": 1443, "config": "macos-release-arm64", "r": "4.6.1", "check": "WARNING", "artifact": "8257413403" }, { "job": 86625006294, "time": 214, "config": "source", "r": "4.6.1", "check": "OK", "artifact": "8257193681" }, { "job": 86625251915, "time": 118, "config": "wasm-release", "r": "4.6.0", "check": "OK", "artifact": "8257213594" }, { "job": 86625251932, "time": 1197, "config": "windows-devel", "r": "4.7.0", "check": "WARNING", "artifact": "8257380244" }, { "job": 86625251914, "time": 1338, "config": "windows-oldrel", "r": "4.5.3", "check": "WARNING", "artifact": "8257398416" }, { "job": 86625251933, "time": 1196, "config": "windows-release", "r": "4.6.1", "check": "WARNING", "artifact": "8257379952" } ], "_host": "GitHub-Actions", "_buildurl": "https://github.com/r-universe/mrcieu/actions/runs/29183357217", "_status": "success", "_upstream": "https://github.com/lb664/MR2", "_commit": { "id": "ff1774747c312a1d53b747fbf7c161d6155b209e", "author": "Leonardo Bottolo ", "committer": "Leonardo Bottolo ", "message": "Version: 0.1.1\n", "time": 1744022127 }, "_maintainer": { "name": "Leonardo Bottolo", "email": "lb664@cam.ac.uk", "login": "lb664", "description": "Leonardo Bottolo is a Reader of Statistics in Biomedicine at the University of Cambridge.", "uuid": 23554999 }, "_distro": "resolute", "_registered": true, "_dependencies": [ { "package": "BDgraph", "role": "Imports" }, { "package": "graphics", "role": "Imports" }, { "package": "grDevices", "role": "Imports" }, { "package": "MASS", "role": "Imports" }, { "package": "MCMCpack", "role": "Imports" }, { "package": "mvnfast", "role": "Imports" }, { "package": "mvtnorm", "role": "Imports" }, { "package": "Rdpack", "role": "Imports" }, { "package": "truncnorm", "role": "Imports" }, { "package": "utils", "role": "Imports" } ], "_owner": "lb664", "_selfowned": false, "_usedby": 0, "_updates": [], "_tags": [], "_stars": 21, "_contributors": [ { "user": "lb664", "count": 1, "uuid": 23554999 } ], "_userbio": { "uuid": 15654827, "type": "organization", "name": "MRC Integrative Epidemiology Unit", "followers": 251 }, "_downloads": { "count": 0, "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/MR2" }, "_devurl": "https://github.com/lb664/mr2", "_searchresults": 2, "_rbuild": "4.6.1", "_assets": [ "extra/citation.cff", "extra/citation.html", "extra/citation.json", "extra/citation.txt", "extra/contents.json", "extra/MR2.html", "extra/readme.html", "extra/readme.md", "LICENSE", "manual.pdf" ], "_cranurl": false, "_exports": [ "BMM_EM", "FDR_BMM", "MR2", "PostProc", "Scenario_Confounding", "Scenario_Dependence", "Scenario_Mediation", "Scenario_Pleiotropy" ], "_help": [ { "page": "BMM_EM", "title": "Beta density finite mixture model", "topics": [ "BMM_EM" ] }, { "page": "FDR_BMM", "title": "False Discovery Rate based on Beta densities finite mixture model", "topics": [ "FDR_BMM" ] }, { "page": "MR2", "title": "MR2: Multi-response Mendelian randomization", "topics": [ "MR2" ] }, { "page": "PostProc", "title": "Post-processing of MR2 output", "topics": [ "PostProc" ] }, { "page": "Scenario_Confounding", "title": "Simulated scenario: Confounding", "topics": [ "Scenario_Confounding" ] }, { "page": "Scenario_Dependence", "title": "Simulated scenario: Dependence", "topics": [ "Scenario_Dependence" ] }, { "page": "Scenario_Mediation", "title": "Simulated scenario: Mediation", "topics": [ "Scenario_Mediation" ] }, { "page": "Scenario_Pleiotropy", "title": "Simulated scenario: Pleiotropy", "topics": [ "Scenario_Pleiotropy" ] } ], "_readme": "https://github.com/lb664/MR2/raw/HEAD/README.md", "_rundeps": [ "BDgraph", "BH", "cli", "coda", "cpp11", "farver", "ggplot2", "glue", "gtable", "igraph", "isoband", "labeling", "lattice", "lifecycle", "magrittr", "MASS", "Matrix", "MatrixModels", "mcmc", "MCMCpack", "mvnfast", "mvtnorm", "pkgconfig", "pROC", "quantreg", "R6", "rbibutils", "RColorBrewer", "Rcpp", "RcppArmadillo", "Rdpack", "rlang", "S7", "scales", "SparseM", "survival", "truncnorm", "vctrs", "viridisLite", "withr" ], "_score": 3.0211892990699383, "_indexed": false, "_nocasepkg": "mr2", "_universes": [ "mrcieu" ], "_binaries": [ { "r": "4.7.0", "os": "linux", "version": "0.1.1", "date": "2026-07-12T07:00:14.000Z", "distro": "resolute", "commit": "ff1774747c312a1d53b747fbf7c161d6155b209e", "fileid": "https://r2.ropensci.org/979d0b0c5f73b3486170c18604490a3ec23592d22047d7f2d11687280c536b00", "status": "success", "check": "WARNING", "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/29183357217" }, { "r": "4.6.1", "os": "linux", "version": "0.1.1", "date": "2026-07-12T07:00:02.000Z", "distro": "resolute", "commit": "ff1774747c312a1d53b747fbf7c161d6155b209e", "fileid": "https://r2.ropensci.org/d1297361af31f0481743a6dc2bfa2c5b8f3b5d5a05c0362f84c97cc5ddec2f2b", "status": "success", "check": "WARNING", "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/29183357217" }, { "r": "4.5.3", "os": "mac", "version": "0.1.1", "date": "2026-07-12T06:59:19.000Z", "commit": "ff1774747c312a1d53b747fbf7c161d6155b209e", "fileid": "https://r2.ropensci.org/ac55913050f6e478540ca169a0c2cc5cd186ed9572ae6fdbcd69ff676951ceca", "status": "success", "check": "WARNING", "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/29183357217" }, { "r": "4.6.1", "os": "mac", "version": "0.1.1", "date": "2026-07-12T07:00:05.000Z", "commit": "ff1774747c312a1d53b747fbf7c161d6155b209e", "fileid": "https://r2.ropensci.org/65c759a443724406d535a62ed0a6db0cf0f854ef47a25c43a3cdab1df13dbe2d", "status": "success", "check": "WARNING", "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/29183357217" }, { "r": "4.6.0", "os": "wasm", "version": "0.1.1", "date": "2026-07-12T07:00:01.000Z", "commit": "ff1774747c312a1d53b747fbf7c161d6155b209e", "fileid": "https://r2.ropensci.org/f13199c2c4f1615402f3ceed8cf581ce33c5ca5511af5da5901675300248284d", "status": "success", "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/29183357217" }, { "r": "4.7.0", "os": "win", "version": "0.1.1", "date": "2026-07-12T06:59:26.000Z", "commit": "ff1774747c312a1d53b747fbf7c161d6155b209e", "fileid": "https://r2.ropensci.org/09f9a5cd7c83d52767a0f147586b7d4e48cd3e36986606b06ff1c28c389f8a5e", "status": "success", "check": "WARNING", "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/29183357217" }, { "r": "4.5.3", "os": "win", "version": "0.1.1", "date": "2026-07-12T06:59:58.000Z", "commit": "ff1774747c312a1d53b747fbf7c161d6155b209e", "fileid": "https://r2.ropensci.org/06608d5fd00dc0ce032bfcdde8a67022ece7bba657100930813073216cb1604b", "status": "success", "check": "WARNING", "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/29183357217" }, { "r": "4.6.1", "os": "win", "version": "0.1.1", "date": "2026-07-12T06:59:21.000Z", "commit": "ff1774747c312a1d53b747fbf7c161d6155b209e", "fileid": "https://r2.ropensci.org/fae883f867c0dba9a23c3a36a24aa97103f373ffa6dadfbe0c2e99c4a90b1193", "status": "success", "check": "WARNING", "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/29183357217" } ] }