{
  "_id": "6a1ee3efb401979e73410fd5",
  "Package": "TVMR",
  "Type": "Package",
  "Title": "Time-varying Mendelian randomization with time-continous\nmodelling for the effect function",
  "Version": "0.1.0",
  "Author": "Haodong Tian, Ashish Patel",
  "Maintainer": "Haodong Tian <haodong.tian@mrc-bsu.cam.ac.uk>",
  "Description": "Use functional principal components analysis (FPCA) within\nmultivariable Mendelian randomization (MVMR) to estimate the\ntime-varying effect function.",
  "License": "MIT + file LICENSE",
  "Encoding": "UTF-8",
  "Config/pak/sysreqs": "cmake libfontconfig1-dev libfreetype6-dev\nlibfribidi-dev make libharfbuzz-dev libicu-dev libjpeg-dev\nlibpng-dev libtiff-dev libuv1-dev libwebp-dev libxml2-dev\nlibssl-dev libx11-dev zlib1g-dev",
  "Repository": "https://mrcieu.r-universe.dev",
  "Date/Publication": "2025-03-16 19:33:51 UTC",
  "RemoteUrl": "https://github.com/HDTian/TVMR",
  "RemoteRef": "HEAD",
  "RemoteSha": "a7e4983c90745a759f234070cc40d9a4b37bf6c2",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-05-20 06:22:09 UTC",
    "User": "root"
  },
  "MD5sum": "bdaa9cf6e0ea61cec83bf87745b16a08",
  "_user": "mrcieu",
  "_type": "src",
  "_file": "TVMR_0.1.0.tar.gz",
  "_fileid": "e1f4f5554714f211036f8b401d45ae19ffd1851827fa2e1a24221197e432ee18",
  "_filesize": 143236,
  "_sha256": "e1f4f5554714f211036f8b401d45ae19ffd1851827fa2e1a24221197e432ee18",
  "_created": "2026-05-20T06:22:09.000Z",
  "_published": "2026-06-02T14:08:47.045Z",
  "_distro": "noble",
  "_jobs": [
    {
      "job": 79090319352,
      "time": 140,
      "config": "linux-devel-x86_64",
      "r": "4.7.0",
      "check": "WARNING",
      "artifact": "7102727907"
    },
    {
      "job": 79090319593,
      "time": 148,
      "config": "linux-release-x86_64",
      "r": "4.6.0",
      "check": "WARNING",
      "artifact": "7102729898"
    },
    {
      "job": 79090320640,
      "time": 127,
      "config": "macos-oldrel-arm64",
      "r": "4.5.3",
      "check": "WARNING",
      "artifact": "7102723936"
    },
    {
      "job": 79090320349,
      "time": 106,
      "config": "macos-release-arm64",
      "r": "4.6.0",
      "check": "WARNING",
      "artifact": "7102719556"
    },
    {
      "job": 79090318395,
      "time": 195,
      "config": "source",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7102693112"
    },
    {
      "job": 79090318637,
      "time": 120,
      "config": "wasm-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7360080789"
    },
    {
      "job": 79090319904,
      "time": 80,
      "config": "windows-devel",
      "r": "4.7.0",
      "check": "WARNING",
      "artifact": "7102712950"
    },
    {
      "job": 79090319914,
      "time": 83,
      "config": "windows-oldrel",
      "r": "4.5.3",
      "check": "WARNING",
      "artifact": "7102713722"
    },
    {
      "job": 79090319353,
      "time": 77,
      "config": "windows-release",
      "r": "4.6.0",
      "check": "WARNING",
      "artifact": "7102712313"
    }
  ],
  "_buildurl": "https://github.com/r-universe/mrcieu/actions/runs/26145139980",
  "_status": "success",
  "_host": "GitHub-Actions",
  "_upstream": "https://github.com/HDTian/TVMR",
  "_commit": {
    "id": "a7e4983c90745a759f234070cc40d9a4b37bf6c2",
    "author": "HDTian <haodongt1123@gmail.com>",
    "committer": "HDTian <haodongt1123@gmail.com>",
    "message": "license update\n",
    "time": 1742153631
  },
  "_maintainer": {
    "name": "Haodong Tian",
    "email": "haodong.tian@mrc-bsu.cam.ac.uk",
    "login": "hdtian",
    "description": "",
    "uuid": 127906571
  },
  "_registered": true,
  "_dependencies": [
    {
      "package": "stats",
      "role": "Imports"
    },
    {
      "package": "data.table",
      "role": "Imports"
    },
    {
      "package": "tidyverse",
      "role": "Imports"
    },
    {
      "package": "corrplot",
      "role": "Imports"
    },
    {
      "package": "parallel",
      "role": "Imports"
    }
  ],
  "_owner": "hdtian",
  "_selfowned": false,
  "_usedby": 0,
  "_updates": [],
  "_tags": [],
  "_stars": 3,
  "_contributors": [
    {
      "user": "hdtian",
      "count": 57,
      "uuid": 127906571
    }
  ],
  "_userbio": {
    "uuid": 15654827,
    "type": "organization",
    "name": "MRC Integrative Epidemiology Unit"
  },
  "_downloads": {
    "count": 0,
    "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/TVMR"
  },
  "_devurl": "https://github.com/hdtian/tvmr",
  "_searchresults": 2,
  "_rbuild": "4.6.0",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/readme.html",
    "extra/readme.md",
    "extra/TVMR.html",
    "manual.pdf"
  ],
  "_cranurl": false,
  "_exports": [
    "get_true_shape_values",
    "getDat",
    "getLM",
    "getLM_twosample",
    "getX",
    "getY",
    "gmm_lm_onesample",
    "gmm_lm_twosample",
    "indi_plot",
    "IS",
    "MPCMR_GMM",
    "MPCMR_GMM_twosample",
    "MPCMRfit",
    "naiveMPCMRfit",
    "ParMPCMRfit",
    "plotEifun",
    "Qfunction",
    "Qfunction_old"
  ],
  "_help": [
    {
      "page": "getX",
      "title": "simulate a data for the instrument and exposure data with time-varying variable information",
      "topics": [
        "getX"
      ]
    },
    {
      "page": "gmm_lm_onesample",
      "title": "Multivariable GMM and Kleibergen's Lagrange multplier (LM) statistics with one-sample individual-level data",
      "topics": [
        "gmm_lm_onesample"
      ]
    },
    {
      "page": "IS",
      "title": "Instrumental strength with the conditional F statistics",
      "topics": [
        "IS"
      ]
    },
    {
      "page": "MPCMR_GMM",
      "title": "Individual-level data time-varying MR",
      "topics": [
        "MPCMR_GMM"
      ]
    },
    {
      "page": "MPCMR_GMM_twosample",
      "title": "Two-sample time-varying MR fitting",
      "topics": [
        "MPCMR_GMM_twosample"
      ]
    },
    {
      "page": "plotEifun",
      "title": "draw the eigenfunction plot based on a FPCA result",
      "topics": [
        "plotEifun"
      ]
    },
    {
      "page": "Qfunction",
      "title": "Q function",
      "topics": [
        "Qfunction"
      ]
    }
  ],
  "_readme": "https://github.com/HDTian/TVMR/raw/HEAD/README.md",
  "_rundeps": [
    "askpass",
    "backports",
    "base64enc",
    "bit",
    "bit64",
    "blob",
    "broom",
    "bslib",
    "cachem",
    "callr",
    "cellranger",
    "cli",
    "clipr",
    "conflicted",
    "corrplot",
    "cpp11",
    "crayon",
    "curl",
    "data.table",
    "DBI",
    "dbplyr",
    "digest",
    "dplyr",
    "dtplyr",
    "evaluate",
    "farver",
    "fastmap",
    "fontawesome",
    "forcats",
    "fs",
    "gargle",
    "generics",
    "ggplot2",
    "glue",
    "googledrive",
    "googlesheets4",
    "gtable",
    "haven",
    "highr",
    "hms",
    "htmltools",
    "httr",
    "ids",
    "isoband",
    "jquerylib",
    "jsonlite",
    "knitr",
    "labeling",
    "lifecycle",
    "lubridate",
    "magrittr",
    "memoise",
    "mime",
    "modelr",
    "openssl",
    "pillar",
    "pkgconfig",
    "prettyunits",
    "processx",
    "progress",
    "ps",
    "purrr",
    "R6",
    "ragg",
    "rappdirs",
    "RColorBrewer",
    "readr",
    "readxl",
    "rematch",
    "rematch2",
    "reprex",
    "rlang",
    "rmarkdown",
    "rstudioapi",
    "rvest",
    "S7",
    "sass",
    "scales",
    "selectr",
    "stringi",
    "stringr",
    "sys",
    "systemfonts",
    "textshaping",
    "tibble",
    "tidyr",
    "tidyselect",
    "tidyverse",
    "timechange",
    "tinytex",
    "tzdb",
    "utf8",
    "uuid",
    "vctrs",
    "viridisLite",
    "vroom",
    "withr",
    "xfun",
    "xml2",
    "yaml"
  ],
  "_score": 2.1760912590556813,
  "_indexed": false,
  "_nocasepkg": "tvmr",
  "_universes": [
    "mrcieu"
  ],
  "_binaries": [
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "0.1.0",
      "date": "2026-05-20T06:24:30.000Z",
      "distro": "noble",
      "commit": "a7e4983c90745a759f234070cc40d9a4b37bf6c2",
      "fileid": "ca517710966b1d8af1ae253ec221d920c1a8c98097c2937164e47c9a401b19eb",
      "status": "success",
      "check": "WARNING",
      "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/26145139980"
    },
    {
      "r": "4.6.0",
      "os": "linux",
      "version": "0.1.0",
      "date": "2026-05-20T06:24:37.000Z",
      "distro": "noble",
      "commit": "a7e4983c90745a759f234070cc40d9a4b37bf6c2",
      "fileid": "bc49d6e393eb50b443ebc6fdde7296a205ec10380ce807081656131227910464",
      "status": "success",
      "check": "WARNING",
      "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/26145139980"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "0.1.0",
      "date": "2026-05-20T06:24:12.000Z",
      "commit": "a7e4983c90745a759f234070cc40d9a4b37bf6c2",
      "fileid": "9a72fe4011f3b4bc8f83f1db7945162c0f873f2c40d9d8efea1d1d3acc86c1c5",
      "status": "success",
      "check": "WARNING",
      "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/26145139980"
    },
    {
      "r": "4.6.0",
      "os": "mac",
      "version": "0.1.0",
      "date": "2026-05-20T06:23:58.000Z",
      "commit": "a7e4983c90745a759f234070cc40d9a4b37bf6c2",
      "fileid": "ac9603f09a80699ea8bda27cea799c21ce4d3e1997963852e8e26d1b12b0a113",
      "status": "success",
      "check": "WARNING",
      "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/26145139980"
    },
    {
      "r": "4.7.0",
      "os": "win",
      "version": "0.1.0",
      "date": "2026-05-20T06:23:25.000Z",
      "commit": "a7e4983c90745a759f234070cc40d9a4b37bf6c2",
      "fileid": "ef0611d48384bc3b97bf02780159a50d325763a587546389e928077bf59fac57",
      "status": "success",
      "check": "WARNING",
      "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/26145139980"
    },
    {
      "r": "4.5.3",
      "os": "win",
      "version": "0.1.0",
      "date": "2026-05-20T06:23:28.000Z",
      "commit": "a7e4983c90745a759f234070cc40d9a4b37bf6c2",
      "fileid": "e9c8b480fcc0c2ad7202dbb292ae973e71e757180b76a866a2e02690046f44b8",
      "status": "success",
      "check": "WARNING",
      "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/26145139980"
    },
    {
      "r": "4.6.0",
      "os": "win",
      "version": "0.1.0",
      "date": "2026-05-20T06:23:24.000Z",
      "commit": "a7e4983c90745a759f234070cc40d9a4b37bf6c2",
      "fileid": "d73272b03ae1c66199d61491392e4dfab49359b13e985a3230c30b4adc8d8f2e",
      "status": "success",
      "check": "WARNING",
      "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/26145139980"
    },
    {
      "r": "4.6.0",
      "os": "wasm",
      "version": "0.1.0",
      "date": "2026-06-02T14:08:24.000Z",
      "commit": "a7e4983c90745a759f234070cc40d9a4b37bf6c2",
      "fileid": "dc53147bd941a2a442fe49a235652bc0e66766c226d7434cd26309207e23d3e0",
      "status": "success",
      "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/26145139980"
    }
  ]
}