{
  "_id": "6a2951b7732311cd875af68a",
  "Package": "tryx",
  "Title": "MR-TRYX (treasure your exceptions)",
  "Version": "0.2.0",
  "Authors@R": "c(person(\"Gibran\", \"Hemani\", email = \"g.hemani@bristol.ac.uk\", role = c(\"aut\", \"cre\")), person(\"Yoonsu\", \"Cho\", email = \"yoonsu.cho@bristol.ac.uk\", role = c(\"aut\")))",
  "Description": "Heterogeneity in MR analyses can arise due to horizontal\npleiotropy. This package uses MR-Base to identify possible\ntraits that can explain the heterogeneity, with a view to\nidentifying novel putative associations, and adjusting for\ntheir influences to reduce heterogeneity and improve power.",
  "License": "MIT + file LICENSE",
  "Encoding": "UTF-8",
  "RoxygenNote": "7.0.2",
  "Config/pak/sysreqs": "cmake make libicu-dev libuv1-dev libssl-dev",
  "Repository": "https://mrcieu.r-universe.dev",
  "Date/Publication": "2020-07-24 14:00:05 UTC",
  "RemoteUrl": "https://github.com/explodecomputer/tryx",
  "RemoteRef": "HEAD",
  "RemoteSha": "f86a10402dd12b79a510dbff1764dcddf09707c3",
  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-06-10 11:56:30 UTC",
    "User": "root"
  },
  "Author": "Gibran Hemani [aut, cre],\nYoonsu Cho [aut]",
  "Maintainer": "Gibran Hemani <g.hemani@bristol.ac.uk>",
  "MD5sum": "363f77dcc29de0bf04e2d978b18a6c7a",
  "_user": "mrcieu",
  "_type": "src",
  "_file": "tryx_0.2.0.tar.gz",
  "_fileid": "e1fdbf7e6f212ec6a7a4654d68a2de22d12e992dd5f12d84a49527be96eb99c7",
  "_filesize": 208297,
  "_sha256": "e1fdbf7e6f212ec6a7a4654d68a2de22d12e992dd5f12d84a49527be96eb99c7",
  "_created": "2026-06-10T11:56:30.000Z",
  "_published": "2026-06-10T11:59:51.519Z",
  "_distro": "noble",
  "_jobs": [
    {
      "job": 80552213802,
      "time": 167,
      "config": "linux-devel-x86_64",
      "r": "4.7.0",
      "check": "ERROR",
      "artifact": "7534993921"
    },
    {
      "job": 80552213769,
      "time": 161,
      "config": "linux-release-x86_64",
      "r": "4.6.0",
      "check": "ERROR",
      "artifact": "7534991919"
    },
    {
      "job": 80552213779,
      "time": 119,
      "config": "macos-oldrel-arm64",
      "r": "4.5.3",
      "check": "ERROR",
      "artifact": "7534978692"
    },
    {
      "job": 80552213771,
      "time": 105,
      "config": "macos-release-arm64",
      "r": "4.6.0",
      "check": "ERROR",
      "artifact": "7534976363"
    },
    {
      "job": 80551636728,
      "time": 192,
      "config": "source",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7534936394"
    },
    {
      "job": 80552213812,
      "time": 128,
      "config": "wasm-release",
      "r": "4.6.0",
      "check": "OK",
      "artifact": "7534981052"
    },
    {
      "job": 80552213794,
      "time": 97,
      "config": "windows-devel",
      "r": "4.7.0",
      "check": "ERROR",
      "artifact": "7534970257"
    },
    {
      "job": 80552213815,
      "time": 142,
      "config": "windows-oldrel",
      "r": "4.5.3",
      "check": "ERROR",
      "artifact": "7534985258"
    },
    {
      "job": 80552213795,
      "time": 97,
      "config": "windows-release",
      "r": "4.6.0",
      "check": "ERROR",
      "artifact": "7534970685"
    }
  ],
  "_buildurl": "https://github.com/r-universe/mrcieu/actions/runs/27274327665",
  "_status": "success",
  "_host": "GitHub-Actions",
  "_upstream": "https://github.com/explodecomputer/tryx",
  "_commit": {
    "id": "f86a10402dd12b79a510dbff1764dcddf09707c3",
    "author": "Yoonsu Cho <yoonsu.cho@bristol.ac.uk>",
    "committer": "Yoonsu Cho <yoonsu.cho@bristol.ac.uk>",
    "message": "fix error\n",
    "time": 1595599205
  },
  "_maintainer": {
    "name": "Gibran Hemani",
    "email": "g.hemani@bristol.ac.uk",
    "login": "explodecomputer",
    "description": "",
    "uuid": 1924940
  },
  "_registered": true,
  "_dependencies": [
    {
      "package": "R",
      "version": ">= 3.6.0",
      "role": "Depends"
    },
    {
      "package": "TwoSampleMR",
      "role": "Depends"
    },
    {
      "package": "dplyr",
      "role": "Depends"
    },
    {
      "package": "RadialMR",
      "role": "Depends"
    },
    {
      "package": "magrittr",
      "role": "Depends"
    },
    {
      "package": "tidyr",
      "role": "Depends"
    },
    {
      "package": "ggplot2",
      "role": "Depends"
    },
    {
      "package": "glmnet",
      "role": "Depends"
    },
    {
      "package": "ggrepel",
      "role": "Depends"
    },
    {
      "package": "igraph",
      "role": "Suggests"
    },
    {
      "package": "testthat",
      "role": "Suggests"
    }
  ],
  "_owner": "explodecomputer",
  "_selfowned": false,
  "_usedby": 0,
  "_updates": [],
  "_tags": [],
  "_stars": 10,
  "_contributors": [
    {
      "user": "explodecomputer",
      "count": 77,
      "uuid": 1924940
    },
    {
      "user": "yoonsucho",
      "count": 74,
      "uuid": 35306755
    }
  ],
  "_userbio": {
    "uuid": 15654827,
    "type": "organization",
    "name": "MRC Integrative Epidemiology Unit"
  },
  "_downloads": {
    "count": 0,
    "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/tryx"
  },
  "_devurl": "https://github.com/explodecomputer/tryx",
  "_searchresults": 9,
  "_rbuild": "4.6.0",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/readme.html",
    "extra/readme.md",
    "extra/tryx.html",
    "manual.pdf"
  ],
  "_cranurl": false,
  "_exports": [
    "cochrans_q",
    "Tryx",
    "tryx.adjustment",
    "tryx.analyse",
    "tryx.analyse.mv",
    "tryx.network",
    "tryx.scan",
    "tryx.sig",
    "tryx.simulate",
    "volcano_plot"
  ],
  "_help": [
    {
      "page": "cochrans_q",
      "title": "Cochran's Q statistic",
      "topics": [
        "cochrans_q"
      ]
    },
    {
      "page": "strategy1",
      "title": "MR Strategy 1",
      "topics": [
        "strategy1"
      ]
    },
    {
      "page": "Tryx",
      "title": "Class for MR-TRYX analysis",
      "topics": [
        "Tryx"
      ]
    },
    {
      "page": "tryx.adjustment",
      "title": "Outlier adjustment estimation",
      "topics": [
        "tryx.adjustment"
      ]
    },
    {
      "page": "tryx.analyse",
      "title": "Analyse tryx results",
      "topics": [
        "tryx.analyse"
      ]
    },
    {
      "page": "tryx.analyse.mv",
      "title": "Analyse tryx results",
      "topics": [
        "tryx.analyse.mv"
      ]
    },
    {
      "page": "tryx.network",
      "title": "Plot results from outlier_scan in a network",
      "topics": [
        "tryx.network"
      ]
    },
    {
      "page": "tryx.scan",
      "title": "Outlier scan",
      "topics": [
        "tryx.scan"
      ]
    },
    {
      "page": "tryx.sig",
      "title": "Identify putatively significant associations in the outlier scan",
      "topics": [
        "tryx.sig"
      ]
    },
    {
      "page": "tryx.simulate",
      "title": "Simulate data to test tryx",
      "topics": [
        "tryx.simulate"
      ]
    },
    {
      "page": "volcano_plot",
      "title": "Plot volcano plot of many MR analyses",
      "topics": [
        "volcano_plot"
      ]
    }
  ],
  "_readme": "https://github.com/explodecomputer/tryx/raw/HEAD/README.md",
  "_rundeps": [
    "askpass",
    "base64enc",
    "bslib",
    "cachem",
    "cli",
    "codetools",
    "cowplot",
    "cpp11",
    "crosstalk",
    "curl",
    "data.table",
    "digest",
    "dplyr",
    "evaluate",
    "farver",
    "fastmap",
    "fontawesome",
    "foreach",
    "fs",
    "generics",
    "ggplot2",
    "ggrepel",
    "glmnet",
    "glue",
    "GPArotation",
    "gridExtra",
    "gtable",
    "highr",
    "htmltools",
    "htmlwidgets",
    "httr",
    "ieugwasr",
    "isoband",
    "iterators",
    "jquerylib",
    "jsonlite",
    "knitr",
    "labeling",
    "later",
    "lattice",
    "lazyeval",
    "lifecycle",
    "magrittr",
    "MASS",
    "Matrix",
    "memoise",
    "mime",
    "mnormt",
    "MRMix",
    "MRPRESSO",
    "nlme",
    "openssl",
    "otel",
    "pbapply",
    "pillar",
    "pkgconfig",
    "plotly",
    "promises",
    "psych",
    "purrr",
    "R6",
    "RadialMR",
    "rappdirs",
    "RColorBrewer",
    "Rcpp",
    "RcppEigen",
    "rlang",
    "rmarkdown",
    "S7",
    "sass",
    "scales",
    "shape",
    "stringi",
    "stringr",
    "survival",
    "sys",
    "tibble",
    "tidyr",
    "tidyselect",
    "tinytex",
    "TwoSampleMR",
    "utf8",
    "vctrs",
    "viridisLite",
    "withr",
    "xfun",
    "yaml"
  ],
  "_score": 2.6989700043360187,
  "_indexed": false,
  "_nocasepkg": "tryx",
  "_universes": [
    "mrcieu"
  ],
  "_binaries": [
    {
      "r": "4.7.0",
      "os": "linux",
      "version": "0.2.0",
      "date": "2026-06-10T11:59:02.000Z",
      "distro": "noble",
      "commit": "f86a10402dd12b79a510dbff1764dcddf09707c3",
      "fileid": "983998a4ff7a15888ac12af7aaeb114c9a9ae395e7e3debf7d352c8868122c59",
      "status": "failure",
      "check": "ERROR",
      "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/27274327665"
    },
    {
      "r": "4.6.0",
      "os": "linux",
      "version": "0.2.0",
      "date": "2026-06-10T11:58:58.000Z",
      "distro": "noble",
      "commit": "f86a10402dd12b79a510dbff1764dcddf09707c3",
      "fileid": "1b9cc6f5024622561bb94fe2c2d9a5e8a0c5f425ce28242797a4218040bd1a8d",
      "status": "failure",
      "check": "ERROR",
      "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/27274327665"
    },
    {
      "r": "4.5.3",
      "os": "mac",
      "version": "0.2.0",
      "date": "2026-06-10T11:58:27.000Z",
      "commit": "f86a10402dd12b79a510dbff1764dcddf09707c3",
      "fileid": "49a21b26c4cf1246dbbf825549968bfecdbed34b7d1b8a32686c883f7ab4e31e",
      "status": "failure",
      "check": "ERROR",
      "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/27274327665"
    },
    {
      "r": "4.6.0",
      "os": "mac",
      "version": "0.2.0",
      "date": "2026-06-10T11:58:16.000Z",
      "commit": "f86a10402dd12b79a510dbff1764dcddf09707c3",
      "fileid": "b929411dc6a584485a8c5dec20999f935961c4b87f0b30edb5c1596699d071e2",
      "status": "failure",
      "check": "ERROR",
      "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/27274327665"
    },
    {
      "r": "4.6.0",
      "os": "wasm",
      "version": "0.2.0",
      "date": "2026-06-10T11:58:58.000Z",
      "commit": "f86a10402dd12b79a510dbff1764dcddf09707c3",
      "fileid": "03a8d85b485a79a19b5510baf28f171edb15d9a32f6f2ebe989ebf42c3665803",
      "status": "success",
      "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/27274327665"
    },
    {
      "r": "4.7.0",
      "os": "win",
      "version": "0.2.0",
      "date": "2026-06-10T11:57:51.000Z",
      "commit": "f86a10402dd12b79a510dbff1764dcddf09707c3",
      "fileid": "c5383f6795ca905df8ae09341dca240dd29bad89f8527fc5dd94b3674b022ce1",
      "status": "failure",
      "check": "ERROR",
      "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/27274327665"
    },
    {
      "r": "4.5.3",
      "os": "win",
      "version": "0.2.0",
      "date": "2026-06-10T11:58:30.000Z",
      "commit": "f86a10402dd12b79a510dbff1764dcddf09707c3",
      "fileid": "fd55d9c6e7163857be7d25526b0bb5f663d7874a8827db1be1acf45b41b0b4a9",
      "status": "failure",
      "check": "ERROR",
      "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/27274327665"
    },
    {
      "r": "4.6.0",
      "os": "win",
      "version": "0.2.0",
      "date": "2026-06-10T11:57:51.000Z",
      "commit": "f86a10402dd12b79a510dbff1764dcddf09707c3",
      "fileid": "fae6a2041011949101b3c19ddebb146c049df430b2cfdc84859e89598a1d624e",
      "status": "failure",
      "check": "ERROR",
      "buildurl": "https://github.com/r-universe/mrcieu/actions/runs/27274327665"
    }
  ]
}