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Package: MRPATH 1.0

Daniel

MRPATH: R Package for MR-PATH

This package implements methods for fitting the MR-PATH model.

Authors:Daniel Iong

MRPATH_1.0.tar.gz
MRPATH_1.0.zip(r-4.7)MRPATH_1.0.zip(r-4.6)MRPATH_1.0.zip(r-4.5)
MRPATH_1.0.tgz(r-4.6-x86_64)MRPATH_1.0.tgz(r-4.6-arm64)MRPATH_1.0.tgz(r-4.5-x86_64)MRPATH_1.0.tgz(r-4.5-arm64)
MRPATH_1.0.tar.gz(r-4.7-arm64)MRPATH_1.0.tar.gz(r-4.7-x86_64)MRPATH_1.0.tar.gz(r-4.6-arm64)MRPATH_1.0.tar.gz(r-4.6-x86_64)
MRPATH_1.0.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
DESCRIPTION
card.svg |card.png
MRPATH/json (API)

# Install 'MRPATH' in R:

install.packages('MRPATH', repos = c('https://mrcieu.r-universe.dev', 'https://cloud.r-project.org'))

Bug tracker:https://github.com/remlapmot/mrpath/issues

Uses libs:

openblas– Optimized BLAS
c++– GNU Standard C++ Library v3
openmp– GCC OpenMP (GOMP) support library

Datasets:

bmi_t2d - Effect of Body Mass Index
hdl_chd - Effect of HDL Cholesterol

On CRAN:

openblas cpp openmp

1.70 score 1 scripts 15 exports 71 dependencies

Last updated from:cbb7958091 (on suggestions). Checks:8 WARNING, 2 OK, 3 FAIL. Indexed: no.

Target	Result	Time
linux-devel-arm64	WARNING	207
linux-devel-x86_64	WARNING	267
source / vignettes	OK	300
linux-release-arm64	WARNING	186
linux-release-x86_64	WARNING	231
macos-release-arm64	WARNING	106
macos-release-x86_64	WARNING	271
macos-oldrel-arm64	FAIL	110
macos-oldrel-x86_64	FAIL	202
windows-devel	WARNING	183
windows-release	WARNING	188
windows-oldrel	FAIL	81
wasm-release	OK	155

Exports:computeClusterMembProb computeQ getImportanceSamples loo.cv MR_PATH MR_PATHalt MREM.plotParamTraj MREMalt.scatterplot MRPATH_barplot MRPATH_optimizeInitVals MRPATH_scatterplot MRPATH_selectModel sampleBetas selectModel selectModel_stan

Dependencies:askpass base64enc bslib cachem cli cowplot cpp11 crosstalk curl data.table digest dplyr evaluate farver fastmap fontawesome fs generics ggplot2 glue gtable highr htmltools htmlwidgets httr isoband jquerylib jsonlite knitr labeling later lazyeval lifecycle magrittr memoise mime openssl otel pillar pkgconfig plotly plyr promises purrr R6 rappdirs rbibutils RColorBrewer Rcpp RcppArmadillo RcppDist Rdpack reshape2 rlang rmarkdown S7 sass scales stringi stringr sys tibble tidyr tidyselect tinytex utf8 vctrs viridisLite withr xfun yaml

Citation

Development and contributors

Readme and manuals

Help Manual

Help page	Topics
MR-PATH: A Latent Mixture for Heterogenous Causal Mechanisms in Mendelian Randomization	MRPATH-package MRPATH
Effect of Body Mass Index (BMI) on Type-2 Diabetes (T2D)	bmi_t2d
Cluster membership probabilities in MR-PATH	computeClusterMembProb
Importance Sampling of SNP-specific latent variables in MR-PATH	getImportanceSamples
Effect of HDL Cholesterol (HDL-C) on Coronary Heart Disease (CHD)	hdl_chd
MR-PATH Model Fitting	MR_PATH
MR-PATH Bar Plot	MRPATH_barplot
MR-PATH Initial Value Optimizer	MRPATH_optimizeInitVals
MR-PATH Scatter Plot	MRPATH_scatterplot
Model selection for MR-PATH model using a modified BIC criterion.	MRPATH_selectModel
Probabilistic inference for SNP-specific causal effects in MR-PATH	sampleBetas