Package: mr.raps 0.4.2

Qingyuan Zhao

mr.raps: Two Sample Mendelian Randomization using Robust Adjusted Profile Score

Mendelian randomization is a method of identifying and estimating a confounded causal effect using genetic instrumental variables. This packages implements methods for two-sample Mendelian randomization with summary statistics by using Robust Adjusted Profile Score (RAPS). References: Qingyuan Zhao, Jingshu Wang, Gibran Hemani, Jack Bowden, Dylan S. Small. Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score. <arxiv:1801.09652>; Qingyuan Zhao, Yang Chen, Jingshu Wang, Dylan S. Small. Powerful genome-wide design and robust statistical inference in two-sample summary-data Mendelian randomization. <arxiv:1804.07371>.

Authors:Qingyuan Zhao [aut, cre], Jingshu Wang [aut]

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mr.raps.pdf |mr.raps.html✨
mr.raps/json (API)

# Install 'mr.raps' in R:
install.packages('mr.raps', repos = c('https://mrcieu.r-universe.dev', 'https://cloud.r-project.org'))

Bug tracker:https://github.com/qingyuanzhao/mr.raps/issues

Datasets:
  • bmi.ais - Effect of Body Mass Index
  • bmi.bmi - "Effect" of Body Mass Index
  • bmi.cad - Effect of Body Mass Index
  • bmi.sbp - Effect of Body Mass Index
  • cad.bmi - Effect of Coronary Artery Disease
  • cad.cad - Effect of Coronary Artery Disease
  • crp.cad - Effect of C-Reactive Protein on Coronary Artery Disease
  • lipid.cad - Effect of blood lipids (LDL cholesterol, HDL cholesterol, Triglycerides) on Cardiovascular disease risk

On CRAN:

Conda:

4.33 score 33 stars 1 packages 2.2k downloads 12 exports 49 dependencies

Last updated 3 days agofrom:27b96f31e2. Checks:7 OK, 2 NOTE. Indexed: no.

TargetResultLatest binary
Doc / VignettesOKMar 06 2025
R-4.5-winOKMar 06 2025
R-4.5-macOKMar 06 2025
R-4.5-linuxOKMar 06 2025
R-4.4-winOKMar 06 2025
R-4.4-macOKMar 06 2025
R-4.4-linuxOKMar 06 2025
R-4.3-winNOTEMar 06 2025
R-4.3-macNOTEMar 06 2025

Exports:fit.mixture.modelmodal.plotmr.rapsmr.raps.mlemr.raps.mle.allmr.raps.overdispersedmr.raps.overdispersed.robustmr.raps.scatterplotmr.raps.shrinkagemr.raps.simplemr.raps.simple.robustposterior.mean

Dependencies:askpassclicolorspacecrulcurldata.tablefansifarverggplot2ggrepelgluegridExtragtablehttpcodehttrisobandjsonlitelabelinglatticelifecyclemagrittrMASSMatrixmgcvmimemunsellnlmenortestopensslpillarpkgconfigplyrR6RColorBrewerRcpprlangrootSolversnpsscalesstringistringrsystibbletriebeardurltoolsutf8vctrsviridisLitewithr