Package: ColliderBias 1.0.1

ColliderBias: Adjust collider bias and weak instrument bias in Mendelian Randomisation

This package provides adjustment for collider bias and weak instrument bias in association statistics in the context of a genome-wide association study for a subsequent event, using CWLS (Corrected Weighted Least Squares), MR-RAPS and Slope Hunter. An estimation of true causal effect between disease progression and an exposure of interest can be computed using generalised instrument effect regression with CWBLS (Corrected Weighted Bivariate Least Squares).

Authors:Frank Dudbridge, Siyang Cai