Package: ColliderBias 1.0.1

Frank Dudbridge

ColliderBias: Adjust collider bias and weak instrument bias in Mendelian Randomisation

This package provides adjustment for collider bias and weak instrument bias in association statistics in the context of a genome-wide association study for a subsequent event, using CWLS (Corrected Weighted Least Squares), MR-RAPS and Slope Hunter. An estimation of true causal effect between disease progression and an exposure of interest can be computed using generalised instrument effect regression with CWBLS (Corrected Weighted Bivariate Least Squares).

Authors:Frank Dudbridge, Siyang Cai

ColliderBias_1.0.1.tar.gz
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ColliderBias.pdf |ColliderBias.html✨
ColliderBias/json (API)

# Install 'ColliderBias' in R:

install.packages('ColliderBias', repos = c('https://mrcieu.r-universe.dev', 'https://cloud.r-project.org'))

Bug tracker:https://github.com/siyangcai/colliderbias/issues

Datasets:

testData - Sample simulated genome-wide association study (GWAS) summary statisitcs for analysis.

On CRAN:

2.40 score 1 scripts 2 exports 76 dependencies

Last updated 22 days agofrom:66606d074c. Checks:OK: 7. Indexed: no.

Target	Result	Date
Doc / Vignettes	OK	Nov 01 2024
R-4.5-win	OK	Nov 01 2024
R-4.5-linux	OK	Nov 01 2024
R-4.4-win	OK	Nov 01 2024
R-4.4-mac	OK	Nov 01 2024
R-4.3-win	OK	Nov 01 2024
R-4.3-mac	OK	Nov 01 2024

Exports:CWBLS methodCB

Dependencies:askpass base64enc boot bslib cachem cli colorspace cpp11 crosstalk curl data.table digest dplyr evaluate fansi farver fastmap fontawesome fs generics ggplot2 glue gtable highr htmltools htmlwidgets httr ieugwasr isoband jquerylib jsonlite knitr labeling later lattice lazyeval lifecycle magrittr MASS Matrix mclust memoise mgcv mime mr.raps munsell nlme nortest openssl pillar pkgconfig plotly promises purrr R6 rappdirs RColorBrewer Rcpp rlang rmarkdown sass scales SlopeHunter stringi stringr sys tibble tidyr tidyselect tinytex utf8 vctrs viridisLite withr xfun yaml

Citation

Development and contributors

Readme and manuals

Help Manual

Help page	Topics
Estimate true causal effect in bivariate Mendelian randomization to adjust for collider bias and weak instrument bias.	CWBLS
Adjust association statistics for collider bias and weak instrument bias in Mendelian randomization.	methodCB
Sample simulated genome-wide association study (GWAS) summary statisitcs for analysis.	testData