Package: MRAPSS 0.0.0.9000

MRAPSS: Mendelian Randomization Accounting for Pleiotropy and Sample Structure

Implements the MR-APSS approach to test for the causal effects between an exposure and an outcome disease. MR-APSS is a unified approach to Mendelian Randomization accounting for polygenicity, pleiotropy and sample structure using genome-wide summary statistics. Specifically, MR-APSS uses a background-foreground model to characterize both SNP-exposure effects and SNP-outcome effects estimates, where the background model accounts for confounding from genetic correlation and sample structure and the foreground model captures the valid signal for causal inference.

Authors:Xianghong HU [aut, cre]