thelovelab. To fix this you can add URL: https://mrcieu.r-universe.dev/mrlocus to the package DESCRIPTION file. See also theR-universe documentation.Package: mrlocus 0.0.26
mrlocus: MRLocus - Mendelian Randomization per locus
Mendelian Randomization per locus, leveraging eQTL and GWAS summary statistics, for estimation of gene-to-trait effect size and dispersion.
Authors:
mrlocus_0.0.26.tar.gz
mrlocus_0.0.26.zip(r-4.7)mrlocus_0.0.26.zip(r-4.6)mrlocus_0.0.26.zip(r-4.5)
mrlocus_0.0.26.tgz(r-4.6-x86_64)mrlocus_0.0.26.tgz(r-4.6-arm64)mrlocus_0.0.26.tgz(r-4.5-x86_64)mrlocus_0.0.26.tgz(r-4.5-arm64)
mrlocus_0.0.26.tar.gz(r-4.7-arm64)mrlocus_0.0.26.tar.gz(r-4.7-x86_64)mrlocus_0.0.26.tar.gz(r-4.6-arm64)mrlocus_0.0.26.tar.gz(r-4.6-x86_64)
manual.pdf |manual.html✨
card.svg |card.png
mrlocus/json (API)
NEWS
| # Install 'mrlocus' in R: |
| install.packages('mrlocus', repos = c('https://mrcieu.r-universe.dev', 'https://cloud.r-project.org')) |
Bug tracker:https://github.com/thelovelab/mrlocus/issues
Last updated from:d3dd5068a1. Checks:11 NOTE, 1 OK, 1 FAIL. Indexed: no.
| Target | Result | Time | Files | Syslog |
|---|---|---|---|---|
| linux-devel-arm64 | NOTE | 311 | ||
| linux-devel-x86_64 | NOTE | 282 | ||
| source / vignettes | OK | 395 | ||
| linux-release-arm64 | NOTE | 307 | ||
| linux-release-x86_64 | NOTE | 321 | ||
| macos-release-arm64 | NOTE | 184 | ||
| macos-release-x86_64 | NOTE | 375 | ||
| macos-oldrel-arm64 | NOTE | 202 | ||
| macos-oldrel-x86_64 | NOTE | 491 | ||
| windows-devel | NOTE | 386 | ||
| windows-release | NOTE | 381 | ||
| windows-oldrel | NOTE | 522 | ||
| wasm-release | FAIL | 157 |
Exports:collapseHighCorSNPsextractForSlopefitBetaColocfitSlopeflipAllelesAndGathermakeSimDataForMrlocusnormalizedAllelicSpreadplotInitEstimatesplotMrlocuspriorChecktrimClusters
Dependencies:abindbackportsBHcallrcheckmateclicpp11descdistributionalfarvergenericsggplot2gluegridExtragtableinlineisobandlabelinglifecycleloomagrittrMASSmatrixStatsnumDerivpillarpkgbuildpkgconfigposteriorprocessxpsQuickJSRR6RColorBrewerRcppRcppEigenRcppParallelrlangrstanrstantoolsS7scalesStanHeaderstensorAtibbleutf8vctrsviridisLitewithr
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| MRLocus - see this page for typical order of functions | mrlocus-package mrlocus |
| Collapse high correlation SNPs | collapseHighCorSNPs |
| Extract SNPs from colocalization for slope fitting | extractForSlope |
| Fit the colocalization model per signal cluster | fitBetaColoc |
| Fit the mediation slope model: effect of A on B | fitSlope |
| Flip alleles and gather results into lists | flipAllelesAndGather |
| Make simple simulated summary data | makeSimDataForMrlocus |
| Estimate the normalized allelic spread | normalizedAllelicSpread |
| Plot initial estimates over signal clusters | plotInitEstimates |
| Plot estimates from MRLocus slope fitting step | plotMrlocus |
| Basic prior checks on MRLocus slope fit | priorCheck |
| Trim signal clusters based on pairwise r2 | trimClusters |
