Package: tryx 0.2.0

Gibran Hemani

tryx: MR-TRYX (treasure your exceptions)

Heterogeneity in MR analyses can arise due to horizontal pleiotropy. This package uses MR-Base to identify possible traits that can explain the heterogeneity, with a view to identifying novel putative associations, and adjusting for their influences to reduce heterogeneity and improve power.

Authors:Gibran Hemani [aut, cre], Yoonsu Cho [aut]

tryx_0.2.0.tar.gz
tryx_0.2.0.zip(r-4.5)tryx_0.2.0.zip(r-4.4)tryx_0.2.0.zip(r-4.3)
tryx_0.2.0.tgz(r-4.4-any)tryx_0.2.0.tgz(r-4.3-any)
tryx_0.2.0.tar.gz(r-4.5-noble)tryx_0.2.0.tar.gz(r-4.4-noble)
tryx_0.2.0.tgz(r-4.4-emscripten)tryx_0.2.0.tgz(r-4.3-emscripten)
tryx.pdf |tryx.html✨
tryx/json (API)

# Install 'tryx' in R:

install.packages('tryx', repos = c('https://mrcieu.r-universe.dev', 'https://cloud.r-project.org'))

Bug tracker:https://github.com/explodecomputer/tryx/issues

On CRAN:

2.70 score 10 stars 9 scripts 10 exports 114 dependencies

Last updated 4 years agofrom:f86a10402d. Checks:OK: 1 ERROR: 6. Indexed: no.

Target	Result	Date
Doc / Vignettes	OK	Nov 02 2024
R-4.5-win	ERROR	Nov 02 2024
R-4.5-linux	ERROR	Nov 02 2024
R-4.4-win	ERROR	Nov 02 2024
R-4.4-mac	ERROR	Nov 02 2024
R-4.3-win	ERROR	Nov 02 2024
R-4.3-mac	ERROR	Nov 02 2024

Exports:cochrans_q Tryx tryx.adjustment tryx.analyse tryx.analyse.mv tryx.network tryx.scan tryx.sig tryx.simulate volcano_plot

Dependencies:askpass base64enc bit bit64 boot bslib cachem cli clipr codetools colorspace CompQuadForm cowplot cpp11 crayon crosstalk curl data.table digest dplyr evaluate fansi farver fastmap fontawesome foreach fs generics ggplot2 ggrepel glmnet glue GPArotation gridExtra gtable highr hms htmltools htmlwidgets httr ieugwasr isoband iterators jquerylib jsonlite knitr labeling later lattice lazyeval lifecycle lme4 magrittr MASS mathjaxr Matrix memoise meta metadat metafor mgcv mime minqa mnormt mr.raps MRMix MRPRESSO munsell nlme nloptr nortest numDeriv openssl pbapply pillar pkgconfig plotly plyr prettyunits progress promises psych purrr R6 RadialMR rappdirs RColorBrewer Rcpp RcppEigen readr reshape2 rlang rmarkdown sass scales shape stringi stringr survival sys tibble tidyr tidyselect tinytex TwoSampleMR tzdb utf8 vctrs viridisLite vroom withr xfun xml2 yaml

Citation

Development and contributors

Readme and manuals

Help Manual

Help page	Topics
Cochran's Q statistic	cochrans_q
MR Strategy 1	strategy1
Class for MR-TRYX analysis	Tryx
Outlier adjustment estimation	tryx.adjustment
Analyse tryx results	tryx.analyse
Analyse tryx results	tryx.analyse.mv
Plot results from outlier_scan in a network	tryx.network
Outlier scan	tryx.scan
Identify putatively significant associations in the outlier scan	tryx.sig
Simulate data to test tryx	tryx.simulate
Plot volcano plot of many MR analyses	volcano_plot