Package: tryx 0.2.1

Gibran Hemani

tryx: MR-TRYX (treasure your exceptions)

Heterogeneity in MR analyses can arise due to horizontal pleiotropy. This package uses MR-Base to identify possible traits that can explain the heterogeneity, with a view to identifying novel putative associations, and adjusting for their influences to reduce heterogeneity and improve power.

Authors:Gibran Hemani [aut, cre], Yoonsu Cho [aut]

tryx_0.2.1.tar.gz
tryx_0.2.1.zip(r-4.7-any)tryx_0.2.1.zip(r-4.6-any)tryx_0.2.1.zip(r-4.5-any)
tryx_0.2.1.tgz(r-4.6-any)tryx_0.2.1.tgz(r-4.5-any)
tryx_0.2.1.tar.gz(r-4.7-any)tryx_0.2.1.tar.gz(r-4.6-any)
tryx_0.2.1.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
DESCRIPTION
card.svg |card.png
tryx/json (API)

# Install 'tryx' in R:

install.packages('tryx', repos = c('https://mrcieu.r-universe.dev', 'https://cloud.r-project.org'))

Bug tracker:https://github.com/explodecomputer/tryx/issues

Pkgdown/docs site:https://explodecomputer.github.io

On CRAN:

3.00 score 10 stars 9 scripts 10 exports 87 dependencies

Last updated from:d927e26f39 (on refs/pull/26/head). Checks:9 OK. Indexed: yes.

Target	Result	Time
linux-devel	OK	186
source / vignettes	OK	426
linux-release	OK	192
macos-release	OK	119
macos-oldrel	OK	115
windows-devel	OK	97
windows-release	OK	94
windows-oldrel	OK	91
wasm-release	OK	121

Exports:cochrans_q Tryx tryx.adjustment tryx.analyse tryx.analyse.mv tryx.network tryx.scan tryx.sig tryx.simulate volcano_plot

Dependencies:askpass base64enc bslib cachem cli codetools cowplot cpp11 crosstalk curl data.table digest dplyr evaluate farver fastmap fontawesome foreach fs generics ggplot2 ggrepel glmnet glue GPArotation gridExtra gtable highr htmltools htmlwidgets httr ieugwasr isoband iterators jquerylib jsonlite knitr labeling later lattice lazyeval lifecycle magrittr MASS Matrix memoise mime mnormt MRMix MRPRESSO nlme openssl otel pbapply pillar pkgconfig plotly promises psych purrr R6 RadialMR rappdirs RColorBrewer Rcpp RcppEigen rlang rmarkdown S7 sass scales shape stringi stringr survival sys tibble tidyr tidyselect tinytex TwoSampleMR utf8 vctrs viridisLite withr xfun yaml

Guide to using MR-TRYX

Rendered fromguide.Rmdusingknitr::rmarkdown

Last update: 2026-09-26
Started: 2020-01-24

Citation

Development and contributors

Readme and manuals

Help Manual

Help page	Topics
Cochran's Q statistic	cochrans_q
MR Strategy 1	strategy1
Class for MR-TRYX analysis	Tryx
Outlier adjustment estimation	tryx.adjustment
Analyse tryx results	tryx.analyse
Adjust and analyse the tryx results	tryx.analyse.mv
Plot results from outlier_scan in a network	tryx.network
Outlier scan	tryx.scan
Identify putatively significant associations in the outlier scan	tryx.sig
Simulate data to test tryx	tryx.simulate
Plot volcano plot of many MR analyses	volcano_plot