Package: MRBEE 0.1.0
Noah Lorincz-Comi
MRBEE: Mendelian Randomization using Bias-Corrected Estimating Equation and Iterative Pleiotropy Testing
This package performs multivariate Mendelian randomization. It is characterized by the removal of measurement error bias caused by the estimation error of GWAS effect size estimates using an unbiased estimating function in measurement error analysis. It also utilizes a pleiotropy test to dynamically detect and remove potential pleiotropy, making the causal effect robust to pleiotropy.
Authors:
MRBEE_0.1.0.tar.gz
MRBEE_0.1.0.zip(r-4.5)MRBEE_0.1.0.zip(r-4.4)MRBEE_0.1.0.zip(r-4.3)
MRBEE_0.1.0.tgz(r-4.4-any)MRBEE_0.1.0.tgz(r-4.3-any)
MRBEE_0.1.0.tar.gz(r-4.5-noble)MRBEE_0.1.0.tar.gz(r-4.4-noble)
MRBEE_0.1.0.tgz(r-4.4-emscripten)MRBEE_0.1.0.tgz(r-4.3-emscripten)
MRBEE.pdf |MRBEE.html✨
MRBEE/json (API)
| # Install 'MRBEE' in R: |
| install.packages('MRBEE', repos = c('https://mrcieu.r-universe.dev', 'https://cloud.r-project.org')) |
Bug tracker:https://github.com/noahlorinczcomi/mrbee/issues
- hapmap3 - HapMap3 and UKBB Genotype SNP Data
Last updated 12 days agofrom:6295549a1f. Checks:OK: 1 WARNING: 6. Indexed: no.
| Target | Result | Date |
|---|---|---|
| Doc / Vignettes | OK | Sep 24 2024 |
| R-4.5-win | WARNING | Sep 24 2024 |
| R-4.5-linux | WARNING | Sep 24 2024 |
| R-4.4-win | WARNING | Sep 24 2024 |
| R-4.4-mac | WARNING | Sep 24 2024 |
| R-4.3-win | WARNING | Sep 24 2024 |
| R-4.3-mac | WARNING | Sep 24 2024 |
Exports:errorCovfilter_alignJoint.testMRBEE.IMRPMRBEE.IMRP.EggerMRBEE.IMRP.UV
Dependencies:data.tableFDRestimationlatticeMASSMatrixrbibutilsRdpack
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| Estimate Error Covariance Matrix Using GWAS Insignificant Effects | errorCov |
| Filter and Align GWAS Data to a Reference Panel | filter_align |
| HapMap3 and UKBB Genotype SNP Data | hapmap3 |
| Perform Joint Test on GWAS Summary Data | Joint.test |
| Estimate Causal Effect with MRBEE | MRBEE.IMRP |
| Estimate Causal Effect with MRBEE | MRBEE.IMRP.Egger |
| Univariable MR Estimation using MRBEE Method | MRBEE.IMRP.UV |
