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Package: MRCorge 0.1.0

Wenmin Zhang

MRCorge: Mendelian Randomization based on the core gene hypothesis for polygenic exposures

This package performs Mendelian Randomization (MR) analyses based on the core gene hypothesis for polygenic exposures. MR CORGE identifies a small number of putative core instruments that are more likely to affect genes with a direct biological role in an exposure and obtains causal effect estimates based on these instruments, thereby reducing the risk of horizontal pleiotropy.

Authors:Wenmin Zhang [aut, cre], Tianyuan Lu [aut]

MRCorge_0.1.0.tar.gz
MRCorge_0.1.0.zip(r-4.7)MRCorge_0.1.0.zip(r-4.6)MRCorge_0.1.0.zip(r-4.5)
MRCorge_0.1.0.tgz(r-4.6-any)MRCorge_0.1.0.tgz(r-4.5-any)
MRCorge_0.1.0.tar.gz(r-4.7-any)MRCorge_0.1.0.tar.gz(r-4.6-any)
MRCorge_0.1.0.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
DESCRIPTION
card.svg |card.png
MRCorge/json (API)

# Install 'MRCorge' in R:

install.packages('MRCorge', repos = c('https://mrcieu.r-universe.dev', 'https://cloud.r-project.org'))

Bug tracker:https://github.com/zhwm/mrcorge/issues

Pkgdown/docs site:https://zhwm.github.io

On CRAN:

3.30 score 4 stars 6 scripts 3 exports 86 dependencies

Last updated from:f2464f6e07. Checks:7 WARNING, 2 OK. Indexed: no.

Target	Result	Time
linux-devel-x86_64	WARNING	139
source / vignettes	OK	200
linux-release-x86_64	WARNING	133
macos-release-arm64	WARNING	75
macos-oldrel-arm64	WARNING	88
windows-devel	WARNING	87
windows-release	WARNING	81
windows-oldrel	WARNING	102
wasm-release	OK	155

Exports:mrcorge plot_mrcorge Qstatistic

Dependencies:askpass base64enc bslib cachem cli codetools cowplot cpp11 crosstalk curl data.table digest dplyr evaluate farver fastmap fontawesome foreach fs generics ggplot2 glmnet glue GPArotation gridExtra gtable highr htmltools htmlwidgets httr ieugwasr isoband iterators jquerylib jsonlite knitr labeling later lattice lazyeval lifecycle magrittr MASS Matrix memoise mime mnormt MRMix MRPRESSO nlme openssl otel pbapply pillar pkgconfig plotly promises psych purrr R6 RadialMR rappdirs RColorBrewer Rcpp RcppEigen rlang rmarkdown S7 sass scales shape stringi stringr survival sys tibble tidyr tidyselect tinytex TwoSampleMR utf8 vctrs viridisLite withr xfun yaml

Negative control example: HDL->CAD

Rendered fromHDL_CAD.Rmdusingknitr::rmarkdown

Last update: 2024-07-17
Started: 2024-07-17

Help page	Topics
Perform Mendelian Randomization based on the core gene hypothesis for polygenic exposures	mrcorge
Plot MR CORGE Results	plot_mrcorge
Calculate Q Statistic for Heterogeneity	Qstatistic

Package: MRCorge 0.1.0

MRCorge: Mendelian Randomization based on the core gene hypothesis for polygenic exposures

Citation

Development and contributors

Readme and manuals

Help Manual

Usage by other packages (reverse dependencies)